| 학회 | 한국화학공학회 |
| 학술대회 | 2007년 봄 (04/19 ~ 04/20, 울산 롯데호텔) |
| 권호 | 13권 1호, p.9 |
| 발표분야 | 고분자 |
| 제목 | Morphology controls of self-assembled nanoparticles by the secondary structures of poly(amino acid)s |
| 초록 | PHEA containing amine group in the side chain was synthesized by aminolysis of PSI with 2-aminoethanol and 1,6-hexanediamine. PHEA-g-oligo(L-lysine) was successfully synthesized using living polymerization of α-amino acid-N-carboxyanhydrides. Self-assembled nanoparticles of PHEA-g-oligo(L-lysine) in an aqueous solution was fabricated. The morphology changes of self-assembled nanoparticles were induced by the pH or temperature-responsive conformational transition of specific poly (amino acid) group. The conformational transition of secondary structure of poly (amino acid) group was confirmed by CD (circular dichroism). The morphology of self-assembled nanoparticles are studied by TEM and DLS. The surface plasmon resonance (SPR) biosensor has been widely used to investigate binding event occurring on biological surfaces by the detection of a refractive index change on a gold surface without the need to label molecules. We also, through the SPR study, verify physicochemical properties of conformational transition of poly (amino acid). |
| 저자 | 한고운, 정재현, 이현진, 김종득 |
| 소속 | 한국과학기술원 |
| 키워드 | poly(amino acid); SPR; secondary structure |
| 원문파일 | 초록 보기 |
