| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
37권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Synthesis and Characterization of Thermosensitive Triblock Copolymer Composed of Poly(Ethylene glycol), Poly lacitde, and Poly(N-isopropylacrylamide) for Drug eluting stent |
| 초록 |
Novel thermosensitive triblock copolymer of poly(ethylene glycol-bl-lactide-bl-N-isopropylacrylamide) were synthesized and characterized for a biodegradable coating material of drug eluting stent that could be used to release drugs on intravascular stent to prevent in-stent restenosis. The triblock copolymer was prepared by two step polymerization; ring opening polymerization of L-lactide in the presence of methoxy poly(ethylene glycol) and quasi-living radical polymerization of N-isopropylacrylamide, progressively. The structure of the copolymer was analyzed by FT-IR, ¹H NMR and ¹³C NMR spectroscopy. Surface energy of the copolymer and adhesion of serum albumin were comparatively analyzed to estimate protein adhesion on their surface. Sol-gel transition behavior and release of antiproliferative were investigated. |
| 저자 |
정수진, 임소령, 김자원, 김홍성
|
| 소속 |
부산대 |
| 키워드 |
drug release; drug eluting stent; poly(L-lactide); poly(ethylene glycol); N-isopropylacrylamide; methotraxate; thermosensitive
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| E-Mail |
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