| 학회 | 한국화학공학회 |
| 학술대회 | 2008년 가을 (10/23 ~ 10/24, 부산 BEXCO) |
| 권호 | 14권 2호, p.2772 |
| 발표분야 | 생물화공 |
| 제목 | High-Sensitive SurfacePlasmon Resonance Immunosensor for β-amyloid (1-40) |
| 초록 | Numerous studies have indetified β-amyloid (1-40) in cerebrospinal fluid as a potential biomarker for Alzheimer’s disease. It is of particular interest to establish the diagnosis before reaching the clinical severity. The present work report a novel surface plasmon resonance (SPR) based ultrasensitive detection method of β-amyloid (1-40). The sensitivity enhancements of the SPR based immunosensor for β-amyloid (1-40) is done by using gold (Au) nanoparticle-antibody conjugates. The signal enhancing effects of Au-nanoparticle antibody conjugates. The signal enhancing effects of Au-nanoparticle antibody conjugate was found directly proportional with the concentration of the antibody having a detection limit of 1fg/ml. Acknowledgments : This research was supported by The Nano/Bio Science & Technology Program (M10536090001-05N3609-00110) of the Ministry of Education, Science and Technology (MEST), by Ministry of Environment of the Republic of Korea as "The Eco-technopia 21 project", and by The Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea government (MEST) (2006-05374) |
| 저자 | 이진호, 강다연, 김상욱, 예철헌, 오병근, 최정우 |
| 소속 | 서강대 |
| 키워드 | biosensor; nanobiochip; alzheimer; SPR; β-amyloid |
| 원문파일 | 초록 보기 |
