| 초록 |
Biodegradable and hydrophobic nanoparticles have been extensively investigated as delivery systems for various drugs biologically active genes. Sustained release characteristics of nanoparticles reduce the need for frequent administrations and enhance patient compliance by maintaining in vivo drug levels in the therapeutic range. Nevertheless, there are problems associated with the use of these systems for hydrophilic drug and gene delivery. Insolubility of hydrophilic drug and gene instability have been observed during the preparation of nanoparticle. We devised a reverse emulsion-diffusion method for incorporating drugs and gene into sodium alginate nanoparticles and evaluated in vitro their sustained release properties. |
