| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 봄 (04/12 ~ 04/13, 제주 ICC) |
| 권호 |
32권 1호 |
| 발표분야 |
나노바이오기술용 고분자(의료용 고분자 부문위원회) |
| 제목 |
Biocompatible alginate/iron oxide nanoparticles as MRI contrast enhancing agents |
| 초록 |
Metal oxide nanoparticles are becoming increasingly important in medicine for MRI contrast enhancement. Alginate/iron oxide nanoparticle as MRI contrasting agents were prepared by the water-in-oil reverse emulsification-diffusion technique. The approximate size of an alginate nanoparticle where a number of iron oxides were localized was 200 nm. The colloidal solution of nanoparticles showed high stability. The magnetization loops of magnetic composite particles showed very slight hysteresis which is so small to be negligible. A fast and significant decreased MRI signal intensity of the liver was detected immediately after injection of the nanoparticles to living rabbits. A series of in vivo experiments have indicated that the alginate/iron oxide nanoparticles shield toxicity of iron oxide. Suggestively, biocompatible alginate/iron oxide nanoparticles are considered as a strong candidate for MRI contrast enhancing agents. |
| 저자 |
이가현1, 박지애1, 장용민1, 염정현1, 김한도1, 이세근2, 최진현1
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| 소속 |
1경북대, 2대구경북과학기술(연) |
| 키워드 |
nanoparticles; MRI; alginate; iron oxide; reverse emulsification-diffusion
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| E-Mail |
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