| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 봄 (04/12 ~ 04/13, 대전컨벤션센터) |
| 권호 |
37권 1호 |
| 발표분야 |
대학원생 구두발표 |
| 제목 |
Stimuli-responsive core/shell nanogels |
| 초록 |
We present the simple route of pH-responsive hairy nanogels preparation. The poly(ethylene glycol-aspartic acids) (PEG-PAsp) nanogel which has hydrophilic PAsp core and PEG shell was successfully prepared by conversion of hydrophobic core of cross-linked micelle to the hydrophilic core. And the swelling behavior and the structure of nanogels in aqueous solution were analyzed by small angle neutron scattering (SANS). Scattering contributions arising from fluctuations of nanogel network are included in the model expression as a Lorenzian function. And Poly core/shell with contant shell thickness model was selected as a form factor model. Disulfide cross-linked nanogels showed disruption of spherical structure at the reductive environment because of the cleavage of disulfide bonds. Doxorubicin was successfully encapsulated within PAsp core by electrostatic interaction, and doxorubicin loaded nanogels showed improved anticancer effect in vitro. |
| 저자 |
박찬우, 양희만, 김종득
|
| 소속 |
KAIST |
| 키워드 |
Nanogel; SANS; Drug delivery
|
| E-Mail |
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