| 초록 |
Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) has been developed and commercialized as ideal candidates for the substitution of non-biodegradable polymeric materials in application because of their biodegradability and easy processability. The biocompatibility of hydroxyapatite is closely related to its similarities with human hard tissues. Scaffolds consist of PHBV and nano-sized HA were prepared using the salt-leaching and hot-press machine. PHBV/HA was mixed with NaCl by the melting blend method. Then, the scaffolds were immersed into an excess amount of water for dissolving NaCl and the collagen were then immobilized on the surface of PHBV/HA nanocomposites using an 3-aminopropyltriethoxysilane. In this study, the preparation, surface morphologies and mechanical properties of porous PHBV/HA/Collagen are described. The potential of this nanocomposites for use as bone scaffolds was assessed by using osteoblastic cells in terms of adhesion, proliferation and differentiation. |
