| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
의료용 고분자 부문위원회(초청-영어발표/포스터-국문발표 가능) |
| 제목 |
PLGA/magnesium hydroxide nanoparticle composites with synergistic effect of suppressed inflammation and improved mechanical property |
| 초록 |
Although poly(lactic-co-glycolic acid) (PLGA) has many advantages such as biodegradable and biocompatible properties, the biomedical applications have been limited because its hydrolysate causes inflammatory responses in the body. In this study, we prepared magnesium hydroxide nanoparticles grafted with ricinoleic acid and further oligolactide (RA-Mg-OLA) to neutralize the acidic materials rapidly generated during PLGA degradation by increasing the rate of dissolution and additionally to improve the mechanical property of PLGA matrix. Their chemical structure, morphology, pH change, and mechanical properties were analyzed by FTIR, SEM, pH meter, and UTM. RA-Mg-OLA nanoparticles were successfully synthesized and their effect on pH neutralization was confirmed. Consequently, in vitro and in vivo studies demonstrated that the PLGA/RA-Mg-OLA composite could overcome the problems associated with PLGA-based biomedical implants due to positive effects of suppressing inflammation. |
| 저자 |
금창헌1, 조영진1, 정윤기1, 안동준2, 한동근1
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| 소속 |
1한국과학기술(연), 2고려대 |
| 키워드 |
magnesium hydroxide; PLGA; nanocomposite; pH neutralization; inflammation
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| E-Mail |
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