| 초록 |
Photodynamic therapy (PDT) is increasingly recognized as an alternative to classical cancer therapies such as chemotherapy and radiotherapy. Chlorin e6 (Ce6) is a second-generation PDT agent; laser irradiation of Ce6 turns into the production of cytotoxic reactive oxygen species (ROS), eventually leading to ablation of tumor tissues. ROS is difficult to diffuse with a short half-life, it only affects tens of nanometers, so the PDT effect depends on the PS location and intracellular quantity. However, most PSs are hydrophobic, making them insoluble in aqueous solution or aggregate easily in the physiological conditions, resulting in lower quantum yield of ROS production. Therefore, effectively delivery and dispersion of the PS into the cell is a critical factor for the PDT effect. In this study, we analyzed the effect of nanoparticles attached with Chlorin e6 using azobenzene on PS dispersion in the cell and observed the anticancer effect. |
