| 학회 |
한국재료학회 |
| 학술대회 |
2012년 가을 (11/07 ~ 11/09, 라카이샌드파인 리조트) |
| 권호 |
18권 2호 |
| 발표분야 |
D. 바이오재료(Biomaterials) |
| 제목 |
Mechanical and In vitro Evaluation of Three Layered Composite Scaffold of BCP, Bioglass and Gelatin Hydrogel for Bone Tissue Engineering |
| 초록 |
In this experiment porous scaffold of Biphasic Calcium Phosphate (BCP) was prepared by sponge replica method. Then coating of 58SP9 Bioactive glass was placed by microwave sintering. Finally there was hydrogel coating crosslinked with EDC (3-(3-dimethyl aminopropyl) carbodiimide). So the final composite scaffold remained porous but mechanical properties rose considerably. The scaffold was characterized by several experiments such as SEM, EDX, XRD, FT-IR. Materials properties and morphology was evaluated by compressive strength and porosity measurement. Cytotoxicity was carried out by in vitro experiments such as MTT assay and Confocal imaging by using MC3T3-E1 pre-osteoblast cells. Real-time PCR showed the effective gene expression by the scaffold system. All the data showed that final prepared composite scaffold was significantly better compared to conventional BCP scaffold from both mechanical and biological view point. |
| 저자 |
Subrata Deb Nath1, Byong-Taek Lee1, Young-Ki Min2, Hun-Mo Yang3
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| 소속 |
1Department of Biomedical Engineering and Materials and Institute of Tissue regeneration Soonchunhyang Univ., 22Department of Physiology, 3College of Medicine |
| 키워드 |
BCP; Bioglass; Gelatin; Sponge replica
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| E-Mail |
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