| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 가을 (10/31 ~ 11/02, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
22권 2호 |
| 발표분야 |
생물공학_포스터 |
| 제목 |
A scalable production of photosynthetic squalene in engineered Synechococcus elongatus PCC 7942 |
| 초록 |
Metabolic engineering of cyanobacteria has enabled photosynthetic conversion of CO2 to value added chemicals as bio-solar cell factories. Here, we engineered S. elongatus PCC 7942 with modular metabolic pathways consisting of the methylerythritol phosphate pathway enzymes and the squalene synthase which was fused with the β-subunit of phycocyanin(CpcB1) for increasing of squalene. After determination of the observation of a sole droplet of squalene in a cyanobacterium, the best squalene producer was cultivated in a scalable photobioreactor (6 L) with light optimization. Further development of the photo-bioprocessing conditions with strain improvement will promote establishment of an engineered bio-solar cell factory for industrial-scale CO2 conversion.
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| 저자 |
최선영1, 심상준2, 우한민1
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| 소속 |
1성균관대, 2고려대 |
| 키워드 |
Metabolic engineering; Cyanobacteria; Synthetic biology; Isoprenoids; squalene
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| E-Mail |
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