| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 봄 (04/12 ~ 04/13, 제주 ICC) |
| 권호 |
32권 1호 |
| 발표분야 |
나노바이오기술용 고분자(의료용 고분자 부문위원회) |
| 제목 |
Thermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPION) as a dual cancer imaging nanoprobe |
| 초록 |
A multimodal nanoprobe that can detect cancers by both magnetic resonance (MR) imaging and optical fluorescence imaging is presented in this report. A new anti-biofouling polymer, poly(TMSMA-r-PEGMA-r-NHS) synthesized by radical polymerization was used to coat magnetite (Fe3O4) SPION and subsequently, the resulting polymer-coated SPION was further heated above 80℃ to make the final TCL-SPION through cross-linking between silane groups in the polymer coat. Carboxyl groups of TCL-SPION were converted to amine functionalized TCL-SPION which subsequently reacts with near IR dye, Cy5.5 to generate Cy5.5 conjugated TCL-SPION. After i.v. injection of the nanoprobe to LLC bearing nude mice, tumor site was preferentially detected in IVIS optical image as well as in T2-weighted MR image, showing ~68 % signal. Therefore, we expect that the exploitation of such a stable and effective dual imaging nanoprobe would provide great potential for early cancer diagnosis. |
| 저자 |
이혜림1, 유미경1, 박상진1, 정용연2, 전상용1
|
| 소속 |
1광주과학기술원, 2전남대 |
| 키워드 |
MRI; optical imaging; SPION; cancer imaging
|
| E-Mail |
|
