| 초록 |
Nanometer-scale particles are becoming extensive in biomedical applications, especially polymeric micelles as carriers of hydrophobic agents for cancer diagnosis and therapy. Stimuli-responsive polymeric micelles have attracted extensive attention as “smart” materials for biomedical applications, because the polymer structure and property can change responding to external environments such as pH. As for pH-sensitive polymers, the important factor is the presence of ionizable weak acidic or basic units into hydrophobic backbones. After ionization around physiological pH, the coiled polymeric chains extend dramatically as a hydrophilic state due to generating anionic or cationic charges. Herein, we design pH-responsive biodegradable copolymers encapsulating anti-cancer drugs, doxorubicin and magnetite nanoparticles (Fe3O4) for cancer diagnosis and therapy. |
