| 초록 |
A novel biodegradable graft copolymer, dextran-g-poly(1,4-dioxan-2-one) (PODEX), was synthesized through the ring-opening polymerization (ROP) of 1,4-dioxan-2-one (PDO) onto a dextran backbone. Graft copolymers were characterized by FT-IR, 1H and 13C NMR, DSC, TGA and WAXD. Molecular weights of the PODEX copolymers (MW: 94700 ~ 117, 300 daltons), glass transition temperature ( 29 ~ 17 C), melting temperature (82 ~ 100 C) and crystallinity (32 ~ 40%) were increased with the content of PPDO. AFM observations revealed that polymeric micelles were spherical and uniform in morphology with around 30 to 58 nm diameter. Critical micelle concentration (CMC) of self-assembled system was significantly decreased from 3.2 to 1.09 mg/L with the increment of PPDO. This work reports the controlled synthesis of poly(1,4-dioxan-2-one)-grafted dextran copolymers and their efficiency in aqueous dispersion. |
