| 학회 | 한국공업화학회 |
| 학술대회 | 2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 26권 1호 |
| 발표분야 | 포스터-생체재료 |
| 제목 | Bacteria targeted photodynamic therapy through saccharide photosensitizer conjugate |
| 초록 | Helicobacter pylori secretes toxic factors and known to be a major cause ofintestinal diseases. In general, antibiotic-based antibacterial treatment isthe problem that lowers the success rate of treatment by inducing antibioticresistance of H.pylori. Photodynamic therapy is a treatment that caninduce death by a mechanism different from antibiotic resistance. In addition,it has high selectivity compared to normal cells and can effectively treatbacteria. In this study, Photosensitizer was conjugatedto poly amino acid-saccharide (PAS) that can target the protein present in theouter membrane of H.pylori. Conjugation of the PAS was confirmed using 1H-NMRand dynamic laser scattering. In vitro test, MTT assay and confocal laserscanning microscopy (CLSM), the targeting effect and the selectivesterilization effect of H.pylori were confirmed. Through an in vivotest, it was confirmed that the killing effect of PAS in the stomach wassimilar to that of the existing triple drug therapy. |
| 저자 | 임병준1, 임병남1, 신희준1, 이종환1, 김경섭2, 박재명1, 나건1 |
| 소속 | 1가톨릭대, 2유타대 |
| 키워드 | Helicobacter pylori; Photodynamic therapy |
