| 학회 |
한국공업화학회 |
| 학술대회 |
2013년 가을 (10/30 ~ 11/01, 대전컨벤션센터) |
| 권호 |
17권 2호 |
| 발표분야 |
포스터-정밀화학 |
| 제목 |
Redox and pH-sensitive novel polymeric nanoparticle of antifungal agent |
| 초록 |
In this study, redox and pH-sensitive novel polymeric nanoparticle was prepared for efficient delivery of antifungal drug. Amphotericin B (AmB) was mainly used in medical filed, which was effective in the fungal infection. But AmB has a few problems, nephrotoxicity, high insolubility and toxicity. Poly(Ethylene glycol)(PEG) was conjugated to improve solubility of AmB, and that was grafted to O-carboxymethyl chitosan with disulfide bond. The nanoparticle was charicterized by fourier transform infrared spectroscopy (FT-IR), proton nuclear magnetic resonance spectroscopy (1H-NMR), dynamic light scattering (DLS) and high-performance liquid chromatography (HPLC). This research was supported by Basic Science Research Program through the National Research Foundation of korea (NRF) funded by the Ministry of education. Science and Technology (NRF-2012R1A2A2A01014898). |
| 저자 |
장재영, 김남홍, 김원석, 박준규, 남정표, 박성철, 최창용, 장미경, 나재운
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| 소속 |
순천대 |
| 키워드 |
antifungal drug; nanoparticle; fungal infection; pH-sensitive release
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| E-Mail |
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