| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 봄 (04/14 ~ 04/15, 전경련회관) |
| 권호 | 30권 1호, p.653 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Characterization of surface-modified magnetite nanoparticles and their biomedical application |
| 초록 | Biocompatible magnetic nanoparticles such as magnetite have been widely used for in-vivo biomedical applications including magnetic resonance (MR) imaging contrast enhancement.1 However, magnetite nanoparticles have a tendency to aggregation because of their large surface area to volume ratio. The surface modification of nanoparticles is unique method to solve this problem. In this study, lactobionic acid (LA) and fluorescein were used for the surface modification. First, magnetite nanoparticles showing well-dispersion were synthesized using Fe(Ⅱ) and Fe(Ⅲ) salt chemical coprecipication with sodium hydroxide (NaOH) in an aqueous solution. And the magnetite nanoparticles were reacted with 3-(aminopropyl)-trimethoxysilane to produce amino groups on the surface.2 Finally, silica-coated magnetite nanoparticles were surface-modified with LA and fluorescein. The surface modification of magnetite nanoparticles internalized into rat hapatocyte was visualized using both florescence and confocal microscopy. Transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectrometer (FT-IR) and Elemental analyzer (EA) measurements were employed to examine the magnetite nanoparticles properties. References 1. Yong Zhang, Nathan Kohler, and Miqin Zhang, Biomaterials, 23,1553, (2002) 2. Yonghui Deng, Wuil Yang, Changchun Wang and Shoukuan Fu,Adv.Mater.,15,1729, (2003) |
| 저자 | 박미진, 강인규 |
| 소속 | 경북대 |
| 키워드 | magnetite; hepatocyte |
