| 학회 | 한국공업화학회 |
| 학술대회 | 2016년 가을 (10/26 ~ 10/28, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 | 20권 2호 |
| 발표분야 | 정밀화학_포스터 |
| 제목 | L-Proline-Catalyzed Construction of Polyfunctionalized Pyridines via Oxidative N- Annulation |
| 초록 | Pyridines and their derivatives are fundamental heterocyclic compounds contained in natural products and pharmaceuticals. They are also used in the synthesis of bioactive natural products and materials with photo- or electrochemical properties. Representative methods for the synthesis of pyridine derivatives mainly include condensation of 1,3-dicarbonyl compounds1 and organocatalyzed cycloaddition reactions.2 However, environmentally benign methods for the synthesis of pyridines are still highly desirable. Herein, we present L-proline catalyzed reaction for highly functionalized pyridines starting from ketones, α,β-unsaturated aldehydes, and ammonium acetate.3 This protocol proceeds via N-annulation through C-C and C-N bond formation in a single step. 1. Liéby-Muller, F.; Allais, C.; Constantieux, T.; Rodriguez, J. Chem. Commun. 2008, 4207. 2. Colby, D. A.; Bergman, R. G.; Ellman, J. A. J. Am. Chem. Soc. 2008, 130, 3645. 3. Khanal, H. D; Lee, Y. R. Chem. Commun. 2015, 51, 9467. |
| 저자 | 카날하리더더, 이용록 |
| 소속 | 영남대 |
| 키워드 | Organocatalysis; Pyridines; Multicomponent reactions |
