| 초록 |
Diabetes mellitus is a group of metabolic diseases in which a person has high blood sugar, either because the body does not produce enough insulin, or because cells do not respond to the insulin. Translation of islets has been proposed as a safe and effective therapeutic technique. The islets are commonly encapsulated in alginate/poly(l-lysine) hydrogel to suppress the host immune response. However, the low islet isolation efficacy caused by the weak mechanical property of the alginate/PLL hydrogel which can allow hydrogel rupture and thus expose of islet to host immune system is remained a critical limitation for clinical application. To overcome this problem, we developed a hydrophilized porous polycaprolactone-encapsulated alginate microspheres by an immersion precipitation of alginate microspheres into PCL/Pluronic F127 solution. Their morphology, mechanical stability in the PBS, cytotoxicity, and insulin release profile were compared with conventional alginate/PLL microspheres. |
