| 학회 | 한국공업화학회 |
| 학술대회 | 2016년 봄 (05/02 ~ 05/04, 여수 엑스포 컨벤션) |
| 권호 | 20권 1호 |
| 발표분야 | 생체재료_포스터 |
| 제목 | BMP-2 Immobilization by Phosphonated UV-Curable Low-Molecular-Weight Chitosan Derivative on the Surface of Titanium |
| 초록 | The purpose of this study is to immobilize growth factors and coat titanium surfaces using phosphonated UV-curable low-molecular-weight chitosan (Az-P-LM-O-CMC). The structure of the final product was assessed with FT-IR, 31P-NMR, and GPC. The coating of Az-P-LM-O-CMC on titanium was evaluated by measuring water contact angle. Cytotoxicity testing was conducted to determine biocompatibility, and micropatterning was used to check protein immobilization. From the BMP-2 release tests, it was observed that the rate of BMP-2 release could be controlled by multilayer coatings. ALP assay and Ca2+ assay were carried out to evaluate drug immobilization and release effects. Acknowledgements This research was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Science, ICT and future Planning (No. NRF-2014R1A2A1A11052623) |
| 저자 | 정진홍, 김은혜, 한가득, 노승현, 김재원, 손태일 |
| 소속 | 중앙대 |
| 키워드 | Implant; Chitosan; Phosphonate; Protein immobilization; BMP-2; Titanium |
