| 학회 | 한국공업화학회 |
| 학술대회 | 2016년 가을 (10/26 ~ 10/28, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 | 20권 2호 |
| 발표분야 | 생물공학_포스터 |
| 제목 | Topographically Guided Rapid Osteoblast Migration and Enhanced Bone Regeneration |
| 초록 | The rapid recruitment of osteoblasts is a prerequisite step for faster bone regeneration. In this study, we propose a topographically defined polymeric implant (TI) to guide and promote the recruitment of osteoblast into the tissue defect. The microgrooves with parallel arrangement, with radial arrangement, and the non-patterned flat implant was prepared, fabricated with NOA86. As the MC3T3-E1 cells migrated toward the empty area, the migration speed of the cells was faster on line and radial TIs compared to that of flat TI. Meanwhile, the radial TI exhibited faster coverage of defect site compared to line TI since the radial arrangement of microgrooves ‘focused’ the cells more efficiently. These results are supported by PI3K, pAkt, Rac1 downstream signaling mechanism. The proliferation of the cells was also promoted on line and radial TIs, due to decrease of cell-cell contact. Radial TI showed the most efficient bone regeneration in vivo, in accordance to the in vitro results. |
| 저자 | 윤정기, 김병수 |
| 소속 | 서울대 |
| 키워드 | Bone regeneration; Migration; Osteoblast; Topography |
