| 초록 |
Iron oxide nanoparticles have been studied as MR Imaging contrast agents and the successful example for medical applications of inorganic nanoparticles. Alginate is one of the most popular immobilization matrices, which is polysaccharide consisting of linear polymers, and it forms thermally irreversible gels with a divalent cation salt that can be used at high temperatures. Moreover, due to the clear knowledge of diffusion properties, it has studied as a new drug carrier. In vivo, they also could be used for an embolization therapy, one of the extensively studied cancer treatment methods. Herein, we performed size-controlled alginate beads loaded with magnetic nanoparticles, CT contrast agents, and doxorubicin. Doxorubicin releasing was controlled by particle-induced magnetic heating and the delivery pathway and accumulation of beads were able to be evaluated through X-ray CT scan and MR imaging while in vivo injection into cancerous regions via catheter. |
