| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 봄 (04/14 ~ 04/15, 전경련회관) |
| 권호 | 30권 1호, p.99 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Micropatterning of Cells on MMA-based Amphiphilic Nonfouling Surface and its Application |
| 초록 | We investigated the stability of the cell patterns by periodically observing the cells by phase contrast optical microscopy for a month. For square FN patterns, the cell patterns were stable for at least two weeks, and a few connections of adjacent cells were observed after that time. However, some cells were confined to the underlying FN features even after a month. We believe that increasing the interfeature spacing for isolated features like squares should solve this problem. For the stripe patterns, the cells were confined to the FN pattern for up to a month. Compared with the use of bovine serum albumin (BSA) as a cell-repellent background, on which the cell patterns could only be maintained for 1 h, with no pattern remaining after 4 h incubation in serum-containing medium, and oligoethylene glycol-terminated thiols, whose application is limited to gold, the comb polymer’s applicability to diverse substrates such as polymers and metals (e.g., gold) as well as its ability to confine cells to the underlying cell-adhesive pattern for long periods of time indicates its potential to be a broadly suitable template for both short- and long-term cell patterning in a physiological milieu. Fig. 1. Micropatterns of NIH 3T3 fibroblast on the nonfouling polymer surface patterned on TCPS Fig. 2. Micropatterns of porcine anulus fibrosus cells on the nonfouling polymer surface patterned on TCPS 참고문헌 1. Hyun J, Ma H, Zhang Z, Beebe TP, Jr., Chilkoti A., Adv. Mater. 15, 576 (2003). 2. Hyun J, Ma H, Bannerjee P, Cole J, Gonsalves K, Chilkoti A. Langmuir 18, 2975 (2002). |
| 저자 | 현진호1, 김윤아2, 신병철2 |
| 소속 | 1서울대, 2한국화학(연) |
| 키워드 | cell; pattern; nonfouling; amphiphilic |
