| 학회 |
한국공업화학회 |
| 학술대회 |
2007년 봄 (05/11 ~ 05/12, 계명대학교) |
| 권호 |
11권 1호 |
| 발표분야 |
우수논문(구두) |
| 제목 |
Design, synthesis, and screening of new quorum-sensing antagonists based on molecular docking scores |
| 초록 |
A new series of 5 analogues of N-nicotinyl-L-homoserine lactones and 3 analogues of N-sulfonyl-L-homoserine lactones were designed by molecular modeling using SYBYL packages and synthesized by means of the solid phase organic synthesis method. In this method, the carboxamide bond in the N-acyl-L-homoserine lactone (AHL) is replaced either by a sulfonamide or a nicotinamide bond. This was followed by a bacterial test designed to confirm their quorum-sensing inhibition ability, antifouling ability, and antibacterial efficacy. The 8 synthesized compounds were found to be effective as quorum-sensing antagonists, and they were also proven to have antibacterial effects. |
| 저자 |
김철진1, 김재은1, Robert J.C. McLean2, 박형연3, 김찬경3, 윤제용1
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| 소속 |
1서울대, 2Southwest Texas State Univ., 3인하대 |
| 키워드 |
quorum-sensing inhibitors; antagonist; N-nicotinyl-L-homoserine lactones; N-sulfonyl-L-homoserine lactones; binding energies; FlexX docking
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| E-Mail |
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