| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 봄 (04/09 ~ 04/10, 대전컨벤션센터) |
| 권호 |
34권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Microneedle-mediated transdermal delivery of chondroitin sulfate |
| 초록 |
Microneedle-mediated transdermal drug delivery is a non-invasive delivery method for drugs through the various layers of the skin to reach systemic circulation. In this study, we prepared a microneedle dermaroller composed of 3600 microneedles with 230nm in length and examined the effects of microneedle pretreatment on the skin permeation of chondroitin sulfate. It was confirmed that microneedles created microconduits that allow chondroitin sulfate to permeate into skin. The more microneedle treatment created more microconduits, leading to the more permeation of CS-FITC into skin. Microneedle treatment in mutual cross direction is more effective in CS-FITC-permeation than in parallel direction. After microneedle pretreatment, CS-FITC exhibited a more permeation into skin in the formulation of hydrogel than in solution. This work demonstrates the feasibility of microneedle-mediated transdermal delivery of chondroitin sulfate. |
| 저자 |
김윤태, 박현진, 이종문, 유일수, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
chondroitin sulfate; transdermal; Microneedle
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| E-Mail |
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