| 초록 |
Mechanism and regulation of natural protein and peptide assemblies are deeply related to the pathological events associated with various diseases. Natural, artificial peptides may also provide a new platform for the development of advanced nanobiomaterials. In particular, the rational design of peptide amphiphiles can lead to a variety of self-assembling nanoarchitectures such as micelles, cylinders, tubules, and vesicles under physiological conditions. Their secondary structures and subsequent conformational changes provide structural diversity and dynamics in resulting nanostructures. In this talk, I will discuss how to control nanostructures and visualize their molecular organization using cryogenic-transmission electron microscopy. Having in mind the manifold applications for self-assembled nanostructures, the direct visualization and interpretation of supramolecular peptide assembly might be a key nanotechnology for designing next generation bioinspired nanomaterials. |
