| 학회 | 한국공업화학회 |
| 학술대회 | 2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 23권 2호 |
| 발표분야 | 포스터_생체재료 |
| 제목 | Thermo-activable smart photosensitizer for effective photodynamic therapy |
| 초록 | Photosensitizer was exploited tumor therapy because of generated reactive oxygen singlet. However, the hydrophobic PS aggregates in blood vessel and is quenched to decrease its activity. This point was used to treat tumor more efficiency. In this study, PS conjugated temperature dependent reversible polymer (PTDRP). It located at physiological temperature, it was aggregated. When it receives heat, the polymers were aggregated and create a hydrophobic environment. PS is located in hydrophobic environment and it is dispersed and activated. We used the small-angle X-ray scattering to confirm change of polymer structure. PTDRP has a lower critical solution temperature in water. It changed form from random-coil to collapsed when it was heated. Consequently, PTDRP generated more fluorescence, singlet oxygen generation at 45 °C than at 37 °C. At various temperature, we measured cytotoxicity at hyperthermia condition. |
| 저자 | 임병준1, 박우람2, 박신정1, 신희준1, 정영석1, 이병두3, 김동현4, 나건1 |
| 소속 | 1가톨릭대, 2차의과대, 3Argonne National Laboratory, 4Northwestern Univ. |
| 키워드 | Photodynamic therapy; photosensitizer |
