| 초록 |
Template-based mesoporous silica nanoparticles(MSNs) are suitable for drug delivery because of their favorable properties such as good biocompatibility, large loading capacity, ease of surface modification, and tunable pore size. Aptamers are short oligonucleotides for specific, high-affinity binding to a broad range of molecular targets. In this study, we developed DNA/aptamer capped MSNs for drug delivery. After loading of the Rhodamine B as model drugs, pores are capped with hybridization of an aptamer with a complementary oligonucleotide of aptamers. Release of drugs is induced by opening the pore which is initiated by detachment of aptamer from surface of MSNs. |
