| 초록 |
Nanoscopic delivery vehicles capable of encapsulating drug molecules and releasing them in response to external stimuli are of great interest due to implications in therapeutic applications. Micellar assemblies are promising scaffolds to overcome many of the problems faced with traditional chemotherapies. However, the stability of encapsulation with such self-assembled systems is limited during blood circulation because of a requisite concentration for assembly formation. Thus, deliberate molecular design for stable encapsulation, targeting and triggered release is required. For this purpose, we have developed a facile synthetic method for highly stable, polymeric nanogels using a simple intra/inter-chain crosslinking reaction. The resulting nanogels show sizes of several hundred nanometers with well-defined shapes. The nanogel surfaces can be functionalized with specific groups, allowing for potential functionalization for targeted delivery. |
