| 초록 |
Stem cells secrete exosomes containing various proteins and genetic materials, which could act as critical signals of cell-to-cell communication for tissue regeneration. Stem cell exosomes provide a cell-free therapeutic approach for regeneration of various tissues. Exosomes contained various cytokines and microRNAs related to each tissue development. New tissue formations were observed in the exosome injection sites of mouse models. We are now developing several exosome products for the treatment of various human diseases such as osteoarthritis, liver/lung fibrosis, osteoporosis, diabetes/obesity etc. We plan the future hopefully for entry to clinical trials of some exosome products. In this presentation, we hope to discuss several important issues for entry to clinical trials of exosome therapy such as mass production, quality control, CMC documentation, pre-clinical experiments, etc. |
