| 초록 |
Bacterial cellulose nanofibers (BCNFs), are attractive biomaterials, since they are biocompatible and can be easily chemically modified for a variety of biomedical treatments. When primary hydroxyl groups on the BCNFs are substituted to carboxylic groups by oxidation, they are able to physicochemically interact with biomolecules. Herein, we propose a new BCNF-based bioadhesion system for dermal therapy. The essence of our approach is that the antibody-conjugated BCNFs are bound to involucrin in the corneocyte. The BCNF bioadhesives were fabricated by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)/N-hydroxysuccinimide (NHS) coupling reaction of antibody. Then, the adhesion force between the antibody-conjugated BCNFs and porcine skin was characterized by using the axial rheometer measurement. Finally, we demonstrated that our BCNF bioadhesives exhibited such a strong interaction with the skin tissue even under wet conditions, thus promising a variety of biological applications. |
