| 초록 |
Photodynamic therapy (PDT) has evolved into a powerful modality for the treatment of a variety of oncological, cardiovascular, dermatological, and ophthalmic diseases. An effective tumor-targeted drug delivery system for PDT was developed by designing ligand-mediated nanoparticles with stable formulations of photosensitizer. Photosensitizer-loaded nanoparticles (FA-PEG-P(Asp-Hyd)-Pheo) were prepared by micelle formation. The in vitro release profiles of Pheo from the nanoparticles were strongly influenced by pH and the amount of photosensitizer. In vitro cell tests indicated that the FA-PEG-P(Asp-Hyd)-Pheo nanoparticles had excellent cellular localization properties and killed HeLa cells effectively compare to free Pheo under laser radiation. |
