| 학회 |
한국공업화학회 |
| 학술대회 |
2015년 가을 (11/04 ~ 11/06, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 |
19권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Mechanism action of α-helical Peptides in drug-resistant Bacteria |
| 초록 |
Antibiotic-resistant bacteria have been increased due to abuse and misuse of antibiotics in biomedical fields. Therefore, to overcome that, many researchers have been finding new antibiotics. In present study, we designed eight antibacterial peptides. Present study was designed a series of synthetic α-helical peptides with amphiphilicity. They were composed of recurring (XWZX)n-NH2 sequences where X: cationic amino acids, W: tryptophan, Z:hydrophobic amino acids, n: number of repeat units. We analyzed action of eight antimicrobial peptides in drug-resistant bacteria of Pseudomonas aeruginosa and Staphylococcus aureus. The finding in the present study are able to provide basic information on design of effective antibiotic peptides. This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded the Ministry of Education, Science and Technology (2013R1A1A4A01010701). |
| 저자 |
박성철, 장미경, 박영훈, 정재은, 김은지, 김영민, 김남홍
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| 소속 |
순천대 |
| 키워드 |
Peptide; Bacteria; Antibiotics
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| E-Mail |
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