초록 |
Silk has the potential for use as a natural material because of the biocompatibility, degradability, and remarkable mechanical properties. However, although the presence of unique properties of silk leads to biocompatibility and mechanical property compared to synthetic polymeric scaffolds, the lack of reliable and reproducible shape controllability is a drawback. To overcome this problem, nanosized silk powder was electrospun with a biodegradable and biocompatible polymer, polycaprolactone. PCL/silk fibrous composites were fabricated with an electrospinning process. A hydrophilicity, mechanical properties, and cellular behavior of the PCL/silk fibrous scaffold were analyzed. In addition, aligned PCL/silk fibrous webs were fabricated using various collector rotation speeds. As the alignment of micro/nanofibers increased, the hydrophilicity, mechanical properties, and cellular behavior. These results show the potential for using PCL/silk fibrous scaffolds as a good natural biomaterial. |