| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 봄 (04/10 ~ 04/12, 부산컨벤션센터(BEXCO)) |
| 권호 |
44권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Doxorubicin-incorporated oxidation responsive poly(hydroxyethyl acrylate-co-phenyl vinyl sulfide) micelle |
| 초록 |
The copolymer contained hydroxyethyl acrylate (HEA) and phenyl vinyl sulfide (PVS) was prepared free radical method. The oxidation of the sulfide groups of poly (HEA-co-PVS) was confirmed by comparing 1HNMR analysis of poly(HEA-co-PVS) before and after oxidation. The doxorubicin-incorporated poly(HEA-co-PVS) micelle was prepared by dialysis method. The spherical shape of micelle was analyzed transmission electron microscopy (TEM). The toxicity evaluation of poly (HEA-co-PVS) micelle was confirmed by MTT assay in Raw 264.7 cell (normal cell) and KB cell (cancer cell) without micelles without doxorubicin. By comparing free doxorubicin and anticancer efficacy in KB cell, the anticancer efficacy of doxorubicin encapsulated in micelles was confirmed. The cellular internalization of doxorubicin encapsulated in micelles was analyzed by confocal scanning microscopy and flow cytometry compared with free doxorubicin. |
| 저자 |
김태훈, 김진철
|
| 소속 |
강원대 |
| 키워드 |
Doxorubicin; micelle; cellular internalization
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| E-Mail |
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