| 학회 |
한국재료학회 |
| 학술대회 |
2018년 가을 (11/07 ~ 11/09, 여수 디오션리조트) |
| 권호 |
24권 2호 |
| 발표분야 |
B. 나노화학/바이오 재료 분과 |
| 제목 |
Characterization and evaluation of the effect of oxidized cellulose nanofiber–Gelatin hydrogel with Simvastatin loading on Biphasic Calcium Phosphate ceramic scaffold for bone regeneration. |
| 초록 |
Porous Biphasic Calcium Phosphate (BCP) scaffold have been widely used due to their excellent biocompatibility and bioactivity as well as chemical composition. However, ceramic BCP scaffold in bone regeneration historically regarded as nonload-bearing material.The brittleness makes the scaffold limited during implantation and healing to formation of new bone. The concept of addition polymeric hydrogel in ceramic system may raise good mechanical properties and high-level biocompatibility that has attracted much recent days. In this study, a hydrogel system oxidized cellulose nanofiber-gelatin loaded into biphasic calcium phosphate ceramic system to improve the brittleness as well as drug delivery capability. The scaffold contains gelatin and BCP which had osteoconductive and simvastatin had osteoinductive properties. The sustain release of simvastatin had occurred in slow degradation of nanofibrillar cellulose. SEM images showed that the hydrogel successfully filled into the pore system. The mechanical strength data revealed after hydrogel addition the brittleness might overcome during healing process. The FT-IR spectrum showed the hydrogel and drug successfully combined with the BCP scaffold. The drug simvastatin was released from the scaffolds gradually and constantly for up to 30 days, with an initial burst release. In vitro cell-viability studies were conducted using preosteoblasts MC3T3E1 cells. MTT data showed the cell proliferation on the scaffold upto 7 days. Besides MTT, the confocal data represent the cell morphology on the hybrid scaffold. Therefore, this combine system may enhance the suitable application of ceramic scaffold in term of mechanical properties as well as bioactive molecule delivery. |
| 저자 |
Omar Faruq1, Boram Kim2, Byong-Taek Lee3
|
| 소속 |
1Department of Regenerative Medicine, 2College of Medicine, 3Soonchunhyang Univ. |
| 키워드 |
biphasic calcium phosphate; simvastatin; cellulose; bone regeneration |
| E-Mail |
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