| 학회 |
한국고분자학회 |
| 학술대회 |
2016년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
41권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Cholic Acid-Decorated Methyl Cellulose-Polyethylenimine for Drug Delivery System |
| 초록 |
First, methyl cellulose (MC) was oxidized and grafted with polyethylenimine (MW 800 Da). Then, by further modifying with cholic acid, cholic acid conjugated amphiphilic copolymer (MCPEI-CA) was synthesized for drug delivery system. It was expected to form nanoparticles by hydrophobic interaction which can encapsulate hydrophobic drugs. The chemical structure and the critical aggregation concentration of MCPEI-CA was examined. After doxorubicin (DOX) encapsulation, about 250 nm sized nanoparticle was formed and the drug loading content and efficiency were analyzed. Through the MTT test, specific cytotoxicity of MCPEI-CA toward the cancer cells and anticancer activity of MCPEI-CA/DOX, even for the case of MDR cells, were confirmed. These results show the potential of the MCPEI-CA as a drug delivery system for cancer therapy. |
| 저자 |
전주현, 김태완, 유기태, 이경진, 박재홍, 김태일
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| 소속 |
서울대 |
| 키워드 |
Drug delivery system; Polyethylenimine; Methyl cellulose; Cholic acid; Doxorubicin
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| E-Mail |
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