| 학회 |
한국고분자학회 |
| 학술대회 |
2016년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
41권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Bioreducible Micelles Self-Assembled from Poly(ethylene glycol)-Cholesteryl Conjugate as a Drug Delivery Platform |
| 초록 |
A poly(ethylene glycol)-cholesteryl conjugate (Chol-ss-PEG-ss-Chol) connected by cleavable disulfide linkages was synthesized and used as a nanocarrier for in vitro release of doxorubicin (DOX). The micelles formed large aggregates due to the shedding of the PEG shell through cleavage of disulfide bonds in a reductive environment. The in vitro release studies revealed that Chol-ss-PEG-ss-Chol micelles released 80% and approximately 9% of the encapsulated DOX within 6 h under reductive and non-reductive conditions, respectively. The cytotoxicity of DOX-loaded micelles indicated a higher cellular anti-proliferative effect against glutathione (GSH)-pretreated than untreated KB cells. Furthermore, confocal laser scanning microscopy (CLSM) measurement demonstrated that Chol-ss-PEG-ss-Chol micelles exhibited faster drug release in GSH-pretreated than untreated KB cells. These results suggest the potential usefulness of disulfide-based polymeric micelles as controlled drug delivery carriers. |
| 저자 |
하태린, 백철수, 김은주, 정상원, 이세근, 이성준, 김현철
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| 소속 |
대구경북과학기술원 |
| 키워드 |
polymeric micelles; drug delivery system; biocompatible; disulfide-thiol exchange
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| E-Mail |
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