| 학회 |
한국공업화학회 |
| 학술대회 |
2016년 가을 (10/26 ~ 10/28, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 |
20권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Functionalized Polymer dots based Pluronic for Cancer Target Imaging Guided Anticancer Drug Delivery |
| 초록 |
We prepared concentration-mediated multicolor fluorescence based polymer dots (PDs) from sulfuric acid-treated dehydration of Pluronic F-within simple method. Pluronic-based PDs (P-PDs) showed high dispersion stability in solvent media and exhibited a fluorescence emission that was widely tunable from red to blue by adjusting both the excitation wavelengths and the P-PD concentration in an aqueous solution. Based on these facts, we further explore P-PDs for target drug delivery with bio-imaging system. We prepared P-PDs surface decorated drug doxorubicin (DOX) via acid-cleavable hydrazone linkages with tumor target folic acid to obtain the nanoparticles. This system possessed dual function as a deliver and a function of bio-imaging of cancer cells for more advance target delivery system with physiological stability. This was supported by Korea National University of Transportation in 2016. |
| 저자 |
강은비, 박성영, 이기백
|
| 소속 |
한국교통대 |
| 키워드 |
polymer dots (PDs); doxorubicin (DOX); target delivery; bioimaging; Pluronic
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| E-Mail |
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