| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
37권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Synthesis and Characterization of O-Carboxylmethyl Chitosang-poly(ethylene glycol)-Folate as a pH responsive Carrier for Tumor Targeted Drug Delivery |
| 초록 |
Efficient delivery of therapeutics into tumor cells to increase the intracellular drug concentration is a major challenge for cancer therapy due to inefficient cellular uptake. Herein, we have designed a pH-sensitive polymerdrug conjugate nanoparticulate system to overcome the challenges. The nanoparticle is capable of binding with receptor at the tumor extracellular to facilitate cell internalization. Subsequently, the significantly increased acidity in subcellular compartments such as the endosome further promotes doxorubicin release from the endocytosed drug carriers. Drug carrier was characterized in terms of FT-IR, 1H NMR, DLS, TEM, stability and drug release on pH dependent. This research was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Education, Science and Technology(2012-0001621) |
| 저자 |
김태훈, 구태완, 김준호, 김준호, 김원석, 최창용, 김명렬, 나재운, 장미경
|
| 소속 |
순천대 |
| 키워드 |
O-Carboxylmethyl chitosan; pH responsive bond; polymeric drug; doxorubicin
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| E-Mail |
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