| 초록 |
Nanostructured-fibrous scaffold was fabricated by electrospinning of poly(ε-caprolactone) blended with poly(ε-caprolactone)-poly(ethyleneglycol)[PCL-PEG-NH2] diblock copolymers. Upon increasing blend ratios of the diblock copolymers upto 20 %, average diameter of nanofibers significantly increased, showing PEG chains conjugated to PCL interfered an electrospinning process of PCL nanofibers. Above 20 % of blend ratio, nanofibers could not be prepared. A water contact analysis showed that the nanofiber became hydrophilic as the blend ratio increased. Murine fibroblasts were cultivated on the PCL/PCL-PEG nanofibers, confirming PEG had a profound effect on the growth of the cells. Scanning electron microcopy confirmed that fibroblasts on the nanofibers showed distinctive phenotypes compared to those cultivated on cell culture dishes. |
