| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 가을 (10/09 ~ 10/10, 일산킨텍스) |
| 권호 |
33권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Di-/tri-block Copolymer of PEGylated siRNA |
| 초록 |
Small interfering RNAs (siRNAs) are full of promise for the genomic therapeutics because of their high sequence-specificity and inhibition-efficiency to the target cell in mRNA level. But they could be easily broken in the course of the delivery to the target cell and their anionic characteristics prevent the cellular uptake. In our previous studies, the poly(ethyleneglycol) (PEG) was conjugated to the 3’ end of siRNA for protecting from the RNA degradation by the biodegradable-disulfide bond between PEG and siRNA. Now we conjugated PEG to single strand siRNAs via disulfide bond and synthesized A-B and A-B-A copolymer of PEGylated siRNA by hybridization. Then we compared gene silencing effects and serum stabilities between naked and di-/tri-block copolymer of PEGylated siRNA. |
| 저자 |
이수현, 목혜정, 정수연, 박태관
|
| 소속 |
한국과학기술원 |
| 키워드 |
siRNA; PEGylation; multibock copolymer
|
| E-Mail |
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