| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 봄 (04/07 ~ 04/09, 대전컨벤션센터) |
| 권호 |
46권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 Ⅰ |
| 제목 |
Combining reduced graphene oxides, poloxamer, and stem cells for effective photothermal therapy |
| 초록 |
Reduced graphene oxide nanoparticle has been applied to photothermal therapy for treating tumor due to its high absorbance for near-infrared wavelength which is appropriate for in vivo photothermal therapy. However, low tumor targeting property with high ratio of forming aggregates remained as a huddle to overcome. Here, we have demonstrated that poloxamer-conjugated RGOs (pRGOs) laden human mesenchymal stem cells (hMSCs) can improve the specific tumor targeting efficiency and photothermal effect compared to those of conventional method. The pRGOs applied in our study was free from forming aggregate. pRGOs-laden hMSCs injected intravenously to in vivo mouse tumor bearing model showed significantly improved tumor targeting efficiency with heat generation compared to control groups. Our results suggest that combining graphene oxides, poloxamer, and stem cells can increase both tumor targeting efficiency and photothermal effect. |
| 저자 |
박정환, 방석호
|
| 소속 |
성균관대 |
| 키워드 |
Human mesenchymal stem cell; Photothermal therapy; Poloxamer; Reduced graphene oxides
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| E-Mail |
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