| 초록 |
Abstract - Metronidazole, a common antibacterial drug, was incorporated into a hydrophilic polymer matrix composed of carboxymethyl cellulose (CMC) and polyvinyl alcohol (PVA). The CMC and CMC/PVA matrix were prepared by γ-ray irradiation at different doses and tested for its ability to control the release of metronidazole as a drug model. This matrix was characterized by in vitro bioadhesion and in vivo bioavailability study. The results of in vitro study indicated that the release of metronidazole from the only CMC matrix was faster than that of CMC/PVA. Also, the only CMC matrix leads to higher metronidazole absorption relative to that of the CMC/PVA. |
