| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Core-shell Macrobead for pH-Sensitive Drug Delivery |
| 초록 | Selection of hydrogels applied in such processes depends on the characteristics of the gel and the drug or protein. Hydrogels have several important characteristics to be considered in drug diffusion including ionization of the gel, swelling ratio, and reaction to the external environments such as temperature, ionic strength, and pH of the swelling agent. In this study, Chitosan- Hyaluronic acid hydrogels were prepared, and swelling behavior and stimuli-sensitive properties in various pH environment were investigated. Core/shell macrobeads were prepared with the formation of the ionic bonding between amine groups of chitosan and carboxyl groups of hyaluronic acid. Lysozyme was used as a model drug. Cationic Lysozyme in the physiological pH were successfully loaded in the core/shell macrobeads by ionic interacation with anionic core (Hyaluronic acid). With the ion exchange of lysozyme with proton, pH-sensitive release pattern was observed. Reference 1. Guan, Y L, Shao, L, Liu, J, Yao, K, D 1996 PH effect on correlation between water state and swelling kinetics of the crosslinked chitosan/polyether semi-IPN hydrogel. J. Appl. Polym. Sci. 62, 1253-1258. 2. Controlled release of plasmid DNA from photo-cross-linked pluronic hydrogels Biomaterials, Volume 26, Issue 16, June 2005, Pages 3319-3326 |
| 저자 | 이현숙1, 한성균2, 서성미3, 서진아2, 조선행1, 이해방1, 육순홍2 |
| 소속 | 1한국화학(연), 2한남대, 3부경대 |
| 키워드 | hydrogels; Chitosan; Hyaluronic acid |
