| 초록 |
Based on the heat generating property against exogenous laser irradiation, reduced graphene oxide nanoparticles (RGOs) have been widely used for photothermal cancer therapy. It shows high absorbance for near-infrared wavelength that is suitable for in vivo experiment. However, enhancing the tumor-targeting efficiency and evading self-aggregation of RGO to maximize photothermal effect remain challenging. We demonstrated that human mesenchymal stem cells (hMSCs) can deliver poloxamer conjugated RGOs (pRGOs) to target tumors. Self-aggregation limits cellular uptake and requires high nanoparticle concentrations for photothermal effect. But, pRGOs did not show any self-aggregation compared to RGOs. pRGOs-laden hMSCs injected intravenously to tumor-bearing mice show significantly enhanced tumor-targeting efficiency and higher heat generation compared to injections of RGOs after exogenous laser irradiation. |
