| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 가을 (10/08 ~ 10/09, 경북대학교) |
| 권호 | 29권 2호, p.605 |
| 발표분야 | 기능성 고분자 |
| 제목 | The Investigation of Sodium N-lauroyl-L-glutamate and Chitosan Interaction in W/O/W Multiple Emulsion |
| 초록 | Chitosan microcapsules containing the cosmetic active ingredient retinol were prepared by water-in-oil-in-water multiple emulsion(W1/O/W2) in order to enhance retinol stability and control its release rate. Water insoluble membrane of chitosan microcapsules was formed by interacting the cationic chitosan with the sodium lauroyl glutamate(SLG) at the outer O/W interface. The particle size distribution, zeta-potential, retinol loading efficiency, retinol stabilization effect, the retinol release rate from the microcapsules were investigated. Chitosan microcapsules have 4.5~5.0㎛ size distribution. Increasing the SLG concentration in the inner water phase results in increased zeta-potential( Fig.1) and in slower release rate of retinol. Remaining retinol percentages at 45℃ after 30 days in chitosan microcapsules were 54.6%(SLG 0.0%), 65.7%(SLG 0.04%), and 70.5%(SLG 0.08%), respectively( Fig.2). Fig 1. Zeta-potential of chitosan microcapsules with various SLG concentrations Fig 2. Retinol stability in chitosan microcapsules(45℃) 참고문헌 1. A. N. Assimopoulou, V. P. Papageorgiou and C. Kiparissides, J. Microencapsulation, 20, 581(2003) 2. J.A. Ko, H.J. Park, S.J. Hwang, J.B. Park, J.S. Lee, International journal of pharmaceutics, 249, 165-174(2002) |
| 저자 | 이천일1, 차재돈1, 신재섭2 |
| 소속 | 1한불화장품 (연), 2충북대 |
| 키워드 | chitosan; glutamate; emulsion |
