| 초록 |
Poly (ethylene glycol) (PEG) has been applied as crosslinking agent of hydrogel because of advantages that were consist of hydrophilic epoxy based monomer and easy to modify functional group using –OH group. We have increased value of PEO based crosslinking agent by introducing additional functional group as well as crosslinking function. Block copolymer was fabricated through cationic ring opening polymerization (CROP) between PEG and epichlorohydrin and azido group was introduced into inside of chain by substituting for –Cl group. In addition, -OH group of chain end was modified to double bond using esterification. Through three step process, Poly (ethylene glycol) diacrylate containing azido group in the chain was synthesized. Using this as crosslinking agent, hydrogel containing azido group was prepared. Furthermore, high valued functional group such as ferrocene and ether crown could be introduced into hydrogel using ‘click reaction’ and it can be applied to various fields. |
