| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 봄 (04/11 ~ 04/12, 대전컨벤션센터) |
| 권호 |
38권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
A Novel Nitric Oxide Delivery Platform using Bio-Inspired Adhesive Catecholamines |
| 초록 |
Development of a novel strategy for controlled release of nitric oxide (NO) directly from surfaces of medical devices has been a challenging subject for implementing the immense potential of NO in biomedical application. Herein, we describe a facile and versatile strategy for local NO delivery. Simple two-step reactions comprising catecholamine and diazeniumdiolates enable virtually any material surfaces to release NO with appreciable storage. To demonstrate the potential of our strategy in bioapplication, the antibacterial ability was investigated and, the modified surfaces were found to inhibit the bacterial adhesion and kill the adhered bacteria without cytotoxicity. This localized NO-delivery strategy is expected to offer a versatile platform which could trigger the advancement of NO-mediated biomedical domains such as wound healing or anti-restenosis as well as prevention of implant-associated infection. |
| 저자 |
김지훈1, 홍선기2, 이해신3, 김원종3
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| 소속 |
1Department of Chemistry and Center for Self-assembly and Complexity, 2Pohang Univ. of Science and Technology, 3카이스트 |
| 키워드 |
Nitric Oxide; diazeniumdiolates; Dopamine; Catecholamine; Antibacteria
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| E-Mail |
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