| 초록 |
In this study, we prepared the hydrogel film containing the emodin nanoparticles as a wound healing membrane. The cross-linked hydrogel films were prepared with polyvinyl alcohol (PVA) and carboxyl methyl cellulose (CMC) using the freeze-thawing method. Their gel properties, in vitro protein adsorption, release, nitric oxide(NO), in vivo wound healing effect and histopathology were then evaluated. CMC decreased the gel fraction, maximum strength and thermal stability of PVA hydrogel, while it increased the swelling ability, elasticity and porosity of PVA hydrogel. Furthermore, the emodin-loaded wound dressing composed of 1% PVA, 0.15% CMC and 0.25% drug was more swellable, flexible and elastic than PVA alone because of relatively weak cross-linking interaction of CMC with PVA. In wound healing test, this emodin-loaded PVA-CMC hydrogel showed faster healing of the wound made in rat dorsum than the conventional product. |
